A research on the shear stress for “myocardial bridge-coronary artery” analog device

doi:10.3969/j.issn.2095-4344.2014.07.009

Abstract

Abstract:

BACKGROUND: It is difficult to make an exact conclusion about the correlation between atherosclerosis and hemodynamic wall shear stress because of the complexity of the hemodynamic environment in the field of atherosclerosis research.
OBJECTIVE: To analyze the relationship between characteristics of mural coronary artery hemodynamics parameters and atherosclerosis through myocardial bridge-coronary artery analog device.
METHODS: Myocardial bridge-coronary artery analog device was used to simulate experiments in vitro. In the condition of keeping any related parameters unchanged, such as system temperature, the average flow rate and heart rate, we observed and recorded the changes of proximal and distal mean value and oscillatory value of shear stress of mural coronary artery by regulating the oppression level of myocardial bridge to mural coronary artery.
RESULTS AND CONCLUSION: Under 0% oppression, there was no significant difference in distal and proximal mean value and oscillatory value of shear stress of mural coronary artery. Under 50% oppression, the proximal oscillatory value of shear stress was significantly larger than that in the distal end. Under 80% oppression, mean shear stress in the distal end was larger than that in the proximal end. Oscillatory value of shear stress in the proximal end was larger than that in the distal end. With increased oppression, the mean shear stress in the distal end was higher than that in the proximal end, but oscillatory value in the proximal end was higher than that in the distal end. These results indicated that the increase of the oscillatory value of the proximal shear stress of mural coronary artery is an important factor for the occurrence of atherosclerosis.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

全文链接：

Key words: myocardial bridge, coronary vessels, coronary artery disease, hemodynamics

CLC Number:

R318

Ding Hao, Lan Hai-lian, Shang Kun . A research on the shear stress for “myocardial bridge-coronary artery” analog device[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(7): 1033-1038.

Figures/Tables 3

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